Sclerosi Multipla: lettera all’Assessore della Lombardia Mario Melazzini

Chiar.mo prof. Melazzini,

ho letto con interesse questa Sua intervista al Sussidiario:
http://www.ilsussidiario.net/News/Scienze/2012/11/12/SCLEROSI-MULTIPLA-Melazzini-vi-spiego-cosa-e-il-metodo-Zamboni-e-perche-non-lo-sostengo/336981/

Devo però rettificare quanto da lei affermato circa il fatto che non esisterebbero studi confermativi della teoria di Zamboni sulla CCSVI nella SM.

Non avendo alcun dubbio sulla sua perfetta buona fede e tralasciando gli studi ecodoppler (esame assai operatore-dipendente…) dove comunque una recente meta analisi canadese ha trovato una correlazione tra CCSVI e SM, ecco invece gli studi flebografici.

Da uomo di scienza credo che li troverà interessanti.

Con i migliori saluti e auguri.

PS: lasciamo che la ricerca faccia il suo corso senza inutili preconcetti…

JACC Vol 60/17/Suppl B | October 22–26, 2012
Chronic Cerebrospinal Venous Insufficiency: The Association Between the Extent Of Extracranial Venous Anomalies and Clinical Severity and Duration of Multiple Sclerosis.
Juraj Madaric, Andrej Klepanec, Rastislav Bazik, Marek Toth, Terezia Urlandova, Jana Margitfalviova, Juraj Mikulas, Erika Drangova, Daniela Hladikova, Tibor Balazs, Vladimir Neuschl, Ivan Vulev
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOUzJwQ1ZkQV9LR3M

J Vasc Interv Radiol. 2012 Oct;23(10):1302-8. doi: 10.1016/j.jvir.2012.07.010. Epub 2012 Aug 28.
Clinical improvement after extracranial venoplasty in multiple sclerosis.
Hubbard D, Ponec D, Gooding J, Saxon R, Sauder H, Haacke M.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOUnEtS0J2cjJIZU0

AJNR Am J Neuroradiol. 2012 Sep;33(8):1615-20. Epub 2012 Apr 19.
Extracranial venous drainage patterns in patients with multiple sclerosis and healthy controls.
McTaggart RA, Fischbein NJ, Elkins CJ, Hsiao A, Cutalo MJ, Rosenberg J, Dake MD, Zaharchuk G.
PDF: https://docs.google.com/open?id=0B_Ed_wxZvab3dXlfWnpCdDE5V28

Vasc Med. 2012 Jun;17(3):131-7. doi: 10.1177/1358863X12440125. Epub 2012 Apr 10.
Endovascular correction of cerebrovenous anomalies in multiple sclerosis: a retrospective review of an uncontrolled case series.
Dake MD, Dantzker N, Bennett WL, Cooke JP.
PDF: https://docs.google.com/open?id=0B_Ed_wxZvab3Ynk0V2ZKRHVXWGc

Tech Vasc Interv Radiol. 2012 Jun;15(2):144-9. doi: 10.1053/j.tvir.2012.02.007.
Reported outcomes after the endovascular treatment of chronic cerebrospinal venous insufficiency.
Hampson CO, Soares GM, Jaffan AA.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOaEFuOWpMR1ltbjg

Tech Vasc Interv Radiol. 2012 Jun;15(2):121-30. doi: 10.1053/j.tvir.2012.02.005.
Catheter venography and endovascular treatment of chronic cerebrospinal venous insufficiency.
Mandato K, Englander M, Keating L, Vachon J, Siskin GP.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOR2otem50QlRrLWs

Vascular. 2012 Jun;20(3):121-3. Epub 2012 May 10.
Surveillance and medical therapy following endovascular treatment of chronic cerebrospinal venous insufficiency.
Forbes TL, Harris JR, Kribs SW.
PDF: https://docs.google.com/open?id=0B_Ed_wxZvab3cFBFNWctLWZBbzg

Funct Neurol. 2012 Jan-Mar;27(1):55-9.
Venous angioplasty in multiple sclerosis: neurological outcome at two years in a cohort of relapsing-remitting patients.
Salvi F, Bartolomei I, Buccellato E, Galeotti R, Zamboni P.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KObDlIbnE5SFVteEU

Rev Recent Clin Trials. 2012 May;7(2):83-7.
Internal jugular vein valve morphology in the patients with chronic cerebrospinal venous insufficiency (CCSVI); angiographic findings and schematic demonstrations.
Al-Omari MH, Al-Bashir A.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOTGtVVU44RnQxTTA

Phlebology. 2012 Apr 23. [Epub ahead of print] Diagnostic accuracy of current sonographic criteria for the detection of outflow abnormalities in the internal jugular veins.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOSkxocTJJRW16WWM

Phlebology. 2012 Mar;27 Suppl 1:187-9.
Evolution in quality of life and epidemiological impact after endovascular treatment of chronic cerebro-spinal venous insufficiency in patients with multiple sclerosis.
Beelen R, Maene L, Castenmiller P, Decoene V, Degrieck I.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOLW9ERmhMY21iWlU

Phlebology. 2012 Mar;27 Suppl 1:178-86.
The hypothesis of patho-physiological correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis: rationale of treatment.
Lugli M, Morelli M, Guerzoni S, Maleti O.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOd1BxUl9CV09YTTQ

Funct Neurol. 2011 Oct-Dec;26(4):197-203.
Prevalence of extracranial venous abnormalities: results from a sample of 586 multiple sclerosis patients.
Simka M, Latacz P, Ludyga T, Kazibudzki M, Swierad M, Janas P, Piegza J.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOX3Ntdm1vUGFtbnM

J Vasc Interv Radiol. 2012 Jan;23(1):55-9. Epub 2011 Nov 15.
Safety of endovascular treatment of chronic cerebrospinal venous insufficiency: a report of 240 patients with multiple sclerosis.
Mandato KD, Hegener PF, Siskin GP, Haskal ZJ, Englander MJ, Garla S, Mitchell N, Reutzel L, Doti C.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOd05ja0R5WFlhd00

Eur J Vasc Endovasc Surg. 2012 Jan;43(1):116-22. Epub 2011 Aug 11.
Venous angioplasty in patients with multiple sclerosis: results of a pilot study.
Zamboni P, Galeotti R, Weinstock-Guttman B, Kennedy C, Salvi F, Zivadinov R.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOcWNQZkg1N181N0k

Georgian Med News. 2011 Oct;(199):29-34.
Endovascular treatment of patients with chronic cerebrospinal venous insufficiency and multiple sclerosis.
Kipshidze N, Rukhadze I, Archvadze A, Kipiani V, Kipshidze N, Lapiashvili E, Kaloiani V.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KObFpOZE1Zay1XeW8

AJNR Am J Neuroradiol. 2011 Sep;32(8):1482-9. Epub 2011 Jul 14.
Comparison of MR and contrast venography of the cervical venous system in multiple sclerosis.
Zaharchuk G, Fischbein NJ, Rosenberg J, Herfkens RJ, Dake MD.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOaXJmVkZZa3RFMEE

J Endovasc Ther. 2011 Jun;18(3):314-23.
Safety profile of endovascular treatment for chronic cerebrospinal venous insufficiency in patients with multiple sclerosis.
Petrov I, Grozdinski L, Kaninski G, Iliev N, Iloska M, Radev A.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KORXdycm91cEszYkE

Early results of a prospective open-label study on endovascular treatments for chronic cerebrospinal venous insufficiency in the patients with associated multiple sclerosis
Tomasz Ludyga, Marek Kazibudzki, Pawel Latacz, Marcin ´Swierad, Jacek Piegza, Marcin Hartel, Ewa Kluczewska, Marian Simka
Phlebological Review 2011; 19(1):9-14
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KObmNPZ1RfbFpUUGU3Wld1V1FCREtQUQ

Ann Neurol. 2011 Jan;69(1):90-9. doi: 10.1002/ana.22228.
No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset.
Baracchini C, Perini P, Calabrese M, Causin F, Rinaldi F, Gallo P.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOZUNiMjRBUmRicTA

Phlebology. 2010 Dec;25(6):286-95.
Endovascular treatment for chronic cerebrospinal venous insufficiency: is the procedure safe?
Ludyga T, Kazibudzki M, Simka M, Hartel M, Swierad M, Piegza J, Latacz P, Sedlak L, Tochowicz M.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KOaVBkWjkxZjg1STg

J Vasc Surg. 2009 Dec;50(6):1348-58.e1-3.
A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency.
Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Gianesini S, Bartolomei I, Mascoli F, Salvi F.
PDF: https://docs.google.com/open?id=0B0L9MiV9H8KObVV4Mk80ZldLTk0